The data that could save Korosensei sits aboard the International Space Station, out of everyone else's reach. Guided by Korosensei and Ritsu, the class smuggles Nagisa and Karma onto a launching shuttle, sending the two friends into orbit to retrieve it.
Learning that the research they need is held on the space station and shielded from Korosensei by government protection, the class settles on going up themselves. Since the rocket carries only two, they debate who should go, and after the risks are laid out most hands drop. Itona, drawn to the technology, points instead to Nagisa and Karma as the ideal pair. Karma balks at the danger until Nagisa wins him over with the appeal of venturing into space alongside his best friend.
At the launch complex, a small team splits the work: Yada and Kurahashi pose as lost field trip students to distract the control room, Kimura slips in the back so Ritsu can seize the network, and Nagisa and Karma move through tunnels under cover of disabled cameras. Reaching the pad, they ride up to the shuttle, where Korosensei confirms the way is clear and Ritsu loops the internal feed to hide them boarding.
The shuttle launches with Korosensei briefly hitching a ride to coach Nagisa before peeling away, and after docking the two take a crew member hostage with knives and a fake bomb, then explain their goal. The astronauts, unshaken by junior high schoolers, hear them out and hand over copied files in exchange for help unloading supplies. Karma parts with a joke, tossing the harmless bean jelly bomb to the disappointed crew before departure.
Ritsu guarantees a safe return and delights in taking the shuttle as her body for the descent. The pair splash down near the class as Karasuma starts to scold them, only for Korosensei to excuse it as valuable research. Okuda then reads the retrieved data aloud: the larger a tentacled creature, the lower its explosion risk, and a certain drug could cut Korosensei's odds below one percent. The revelation that they might not have to kill him sparks celebration, though Karasuma warns the government will never let a monster live.
The space center is modeled on the real Tanegashima Space Center, and the crew's dismay at the bean jelly plays on the real hazard that beans cause gas, which could endanger spacesuits. The anime stages the vote over who goes in the classroom rather than aboard the station, limits the infiltration party, and moves the break in to about an hour before launch in daylight instead of eight hours ahead at night.

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Karma and Nagisa travel to the International Space Station because research data that could save Korosensei's life is stored there under government protection, and since the rocket can only carry two passengers, the class picks its two best-suited members for the mission.
The class stages a coordinated infiltration at the launch complex, with Yada and Kurahashi distracting the control room, Kimura helping Ritsu hack the network, and Nagisa and Karma slipping through tunnels under cover of disabled cameras.
After docking, they briefly take a crew member hostage with knives and a fake bomb to explain their goal, and the unfazed astronauts hear them out and hand over the copied research files in exchange for help unloading supplies.
Okuda reads that the larger a tentacled creature grows, the lower its explosion risk, and that a certain drug could cut Korosensei's odds of a fatal explosion below one percent.
The class celebrates at the possibility they might not have to kill Korosensei after all, though Karasuma warns that the government will never allow such a dangerous creature to live.
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