The Nerve-Freezing Agent is a lethal drug engineered by Mayuri Kurotsuchi. Injected into an organism's nerves, it locks solid every organ those nerves reach and clots the victim's blood, shutting the body down from the inside.
The Nerve-Freezing Agent is one of the many toxins devised by Mayuri Kurotsuchi, captain of the 12th Division. Delivered straight into a target's nerves, it is built to kill by seizing the body from within, halting the organs those nerves control.
Once the drug reaches the nerves, every organ wired to them freezes in place: eyelids stay locked open, the heart can no longer beat, and the mouth will not close. At the same time the victim's blood thickens and clots, which is enough on its own to prove fatal, and the skin darkens as the compound takes hold. Its one known weakness shows against a target whose skin is layered, since a damaged layer can simply be shed to escape the effect, exactly what Pernida Parnkgjas manages to do.
The agent is the work of Mayuri Kurotsuchi, who wields it during his struggle with Pernida Parnkgjas, the left arm of the Soul King, in the Thousand-Year Blood War. It sits among the arsenal of drugs and devices he engineers as head of Soul Society's Research Institute.

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The Nerve-Freezing Agent is a lethal drug engineered by Mayuri Kurotsuchi, captain of the 12th Division. Injected into an organism's nerves, it is built to kill by seizing the body from within.
The Nerve-Freezing Agent is one of the many toxins devised by Mayuri Kurotsuchi as head of Soul Society's Research Institute.
Once the drug reaches the nerves, every organ wired to them freezes in place, the heart can no longer beat, and the mouth will not close. At the same time the victim's blood thickens and clots, which is enough on its own to prove fatal.
Mayuri wields the Nerve-Freezing Agent during his struggle with Pernida Parnkgjas, the left arm of the Soul King, in the Thousand-Year Blood War.
Its one known weakness shows against a target whose skin is layered, since a damaged layer can simply be shed to escape the effect, exactly what Pernida Parnkgjas manages to do.
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