Kabuto's origins unfold in flashback, tracing his path from an orphanage healer to a spy caught between Danzō's Root and Orochimaru, and the betrayals that drove him to seek his true identity.
Kabuto recalls the days when the Konoha Orphanage took in wounded shinobi, tasking him with tending to an injured Orochimaru. Impressed by the boy's skill, Orochimaru asked whether he wished to become a shinobi, and Kabuto declined, saying the work held no appeal for him. One night, Nonō was confronted at the orphanage by Danzō, who arrived with Orochimaru and Tatsuma Aburame. Danzō pressured her into accepting an intelligence-gathering assignment in Iwagakure, to the distress of the other caretakers.
Kabuto too is drawn into service, sent to infiltrate the villages of the Five Great Shinobi Countries. On a mission in Iwagakure he crosses paths with Nonō, whom he gravely wounds. As he tries to heal her, she stuns him by admitting she no longer remembers who he is. Puzzling over how she could forget him, Kabuto is once again sought out by Orochimaru. Trailing him to a hidden island laboratory, Kabuto learns that Root intends to eliminate both him and Nonō.

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This is episode 336 of Naruto Shippūden, part of the Fourth Shinobi World War: Climax arc, adapting chapters 583 and 584. Confronted with Root's plan to discard him, Kabuto chooses to align himself with Orochimaru and become his personal spy. Later, after Orochimaru's death, Kabuto injects himself with blood taken from the remains, part of his search for what he calls his true self. The episode uses the opening theme Size of the Moon and the ending theme Black Night Town.
The Kabuto Yakushi episode of Naruto: Shippūden recounts Kabuto's origins in flashback, tracing his path from an orphanage healer to a spy caught between Danzō's Root and Orochimaru.
When the young Orochimaru, whom Kabuto had nursed at the orphanage, asks if he wants to become a shinobi, Kabuto declines, saying the work holds no appeal for him.
Kabuto gravely wounds Nonō while on a mission in Iwagakure, and when he tries to heal her, she stuns him by admitting she no longer remembers who he is.
After learning that Root plans to eliminate both him and Nonō, Kabuto chooses to align himself with Orochimaru and become his personal spy.
After Orochimaru's death, Kabuto injects himself with blood taken from Orochimaru's remains, part of his search for what he calls his true self.
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