Guns appear all through the Fullmetal Alchemist story, standard gear for the soldiers and fighters who fill its ranks. Against the regenerating homunculi, though, they count for almost nothing, a gap that quietly measures the reach of ordinary force in a world ruled by alchemy.
Guns see steady use across the Fullmetal Alchemist story, showing up wherever soldiers and armed fighters do. Yet they run into a hard limit against the homunculi.
Bullets simply cannot keep those beings down, since their wounds close over again however many rounds strike home.
Against ordinary opponents these weapons do their job, and Amestris hands them to its troops as standard kit; the regulation sidearm holds close to a dozen shots.
The catch lies entirely in the foe they cannot finish. Because a homunculus seals every wound no matter how many rounds land, gunfire only stalls such an enemy instead of stopping it.
The Amestrian military is the chief body relying on these arms, its infantry carrying the standard pistol as routine gear.
Beyond that sidearm, the wider stock reaches from rifles and shotguns to sniper rifles, with heavier automatics spanning machine guns and their sub-machine cousins, all circulating among the different armed units across the tale.

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Yes, firearms are standard gear throughout Fullmetal Alchemist, used by soldiers and armed fighters across the story. They handle ordinary opponents well but run into a hard limit against the regenerating homunculi.
Firearms are ineffective against homunculi because these beings seal every wound almost immediately, no matter how many rounds strike home. Gunfire can only stall a homunculus rather than stop it.
Fullmetal Alchemist features handguns, rifles, shotguns, sniper rifles, and heavier automatics including machine guns and sub-machine guns, all circulating among the different armed units in the story.
The regulation sidearm issued to Amestrian troops holds close to a dozen shots, serving as standard kit for the military's infantry.
The Amestrian military is the chief user of firearms in Fullmetal Alchemist, issuing standard pistols to its infantry as routine gear alongside a wider stock of rifles, shotguns, and machine guns.
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