Guame

Crocodile and armadillo traits mingle in Guame's squat Beastman frame, a fitting shape for the general who owns the battlefield's ground. His age outstrips every colleague by centuries. In the Parallel Works prequel footage, an animal that appears to be his original form sits at young Lordgenome's side, occupying the same niche Boota later fills for Simon.

Lechery defines Guame as much as loyalty does. He aims snide remarks at whatever is going on between Thymilph and Adiane, and with Nia at his mercy he gropes her, calls her too lovely to destroy, and dangles survival in front of her if she will preside over the settlement that stocks the Spiral King's harem. His attitude toward Lordgenome is respect between old acquaintances rather than the god-worship typical of Beastmen, and he waves Cytomander off as a two-century-old pup, a jab that frames how immense his own age must be.

Going by Parallel Works 8, Guame starts existence as an actual armadillo, the pet who keeps young Lordgenome company and later rides the shoulder of the Spiral General through the first war against the Anti-Spirals. No episode confirms how he turned into a Beastman. Lordgenome could have remade him, whether by splicing genes or by applying Spiral Power, or Guame could have evolved on his own after soaking up his master's energy for years, the path Boota walks near the end of the series. Under the second theory he would rank among the only Beastmen able to channel Spiral Power, since his DNA still carries a double helix; that would explain why so many of his attacks revolve around spinning, and how the Dai-Gundo projects Teppelin's defense, an energy barrier shaped like a giant drill. Fittingly, the Dai-Gundo itself dates back to the era of that first war.

He first appears in Episode 9, joining the other surviving generals to report Thymilph's death to the Spiral King. After his troops take the crew of the Dai-Gurren prisoner, he summons Nia, lays out his own theory of why her father cast her aside, and makes his offer: her life, in exchange for heading Beauty Village, the community that supplies the Spiral King with consorts. She refuses. The prisoners break loose and counterattack, and Simon, pulled out of despair by Nia's encouragement, rescues her personally while destroying Gember, Guame's personal Gunman, forcing the general to retreat. When the brigade assaults Teppelin a month on, Guame strikes in tandem with Cytomander, and after the carrier goes down he channels the capital's power supply through the Dai-Gundo to spin up an enormous tornado meant to wipe out the humans and their reinforcements. Gurren Lagann answers by tunneling under the fortress and impaling it on a drill from below; the thrust runs Guame through as the Dai-Gundo detonates. His name splices guanine, one of DNA's four bases, with the gnome of earth-spirit lore, while his Gunman Gember takes its cue from Genbu, the mythical Black Tortoise. His familiarity with the Spiral Nemesis makes sense for a creature that has shadowed Lordgenome from the very beginning.