Humans are the central race of Tengen Toppa Gurren Lagann, a Spiral species native to Earth. Once the leading Spiral civilization, they are betrayed by their own champion Lordgenome after the Anti-Spiral reveals the Spiral Nemesis, and spend generations hiding underground.
Humanity is a Spiral species, life built on the double helix and able to generate Spiral Power. Within the series they stand as the central race of the universe, with Earth as their home planet.
Before Lordgenome ever takes a throne, humans lead the Spiral races, flourishing openly on their power and covering Earth with cities, Spiral-driven machinery, and huge Spiral constructs. That progress draws the Anti-Spirals, beings of enforced stasis sworn to end all Spiral growth by any means available, mass genocide included. Amid the invasion, an exceptionally strong Spiral named Lordgenome finds a mini-gunmen that becomes the seed of the counterattack, leading armies of gunmen into battle, many of them topped with heads modeled on his discovery. Known first by the titles Spiral Warrior and Spiral Knight, then hailed as the Spiral General, he captains humanity's flagship, the moon-sized Cathedral Terra, with Guame perched at his shoulder.
The war stretches across Lordgenome's long life. Among its cruelest defeats is the Death Spiral Machine, an Anti-Spiral construct that drains Spiral Power and condenses it into dense space faster than any warrior can replenish it, leaving whole fleets of Spiral pilots lifeless in its sea-like expanse; many die against it while trying to reach the enemy homeworld. Neither side relents until the Anti-Spiral, a hive-mind woven from its race's collective wills, visits Lordgenome and reveals the truth behind the campaign, the danger it names the Spiral Nemesis. Thrown into total despair by that knowledge, Lordgenome joins the Anti-Spirals and slaughters his own kind with murderous ease. The scattered survivors are herded underground into hidden villages and patrolled from above by the Beastmen, animals Lordgenome mutates into soldiers, whose gunmen cut down any human who surfaces and keep the rest living in terror.

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Humans are the central Spiral race of Tengen Toppa Gurren Lagann, a species native to Earth that generates Spiral Power and once led all Spiral civilizations before being driven into hiding.
Humans live underground because Lordgenome, after learning of the Anti-Spirals' Spiral Nemesis, joined the enemy and herded the surviving humans into hidden villages, guarding the surface with mutated Beastman soldiers.
Yes, the Spiral King, Lordgenome, is an exceptionally powerful human Spiral who originally led humanity's armies against the Anti-Spirals before betraying his own people.
Lordgenome begins as a heroic Spiral Warrior leading humanity's fight against the Anti-Spirals, but after learning the truth of the Spiral Nemesis he falls into despair, joins the Anti-Spirals, and slaughters his own kind.
Humanity's representative weapon is the Gunman, mechanized war machines fielded in vast armies during the original conflict with the Anti-Spirals and still used generations later against the Beastmen.
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