A brilliant university scientist convinced he can perfect humanity kidnaps students and rebuilds them into obedient super-soldiers. His ReAnimen project drags Invincible into the sewers beneath the campus and ends with a jaw-shattering confrontation.
Once a celebrated student and later a professor at Upstate University, D.A. Sinclair develops a godlike conviction that humanity can be stripped of its flaws through surgery. He abducts people and rebuilds them into ReAnimen, mutilated soldiers granted crushing strength and bent to his will. His first victim, a tipsy student named Doug Cheston, panics at the sight of the unfinished creatures dangling in the lab and is transformed into a raging monster who escapes and tears across the college.
Doug nearly overpowers Invincible until he removes his helmet and glimpses his own ruined face, then takes his own life in despair. Furious at losing his creation, Sinclair vows never again to spare a subject's frontal lobe and seizes William's boyfriend Rick along with three others for his next batch.
Sinclair uses Rick to lure and convert William into a ReAniman. Tracking his friend into the sewers, Invincible is ambushed by three of the creatures who try to drown him before he breaks loose and reaches the lab, where a bound William waits. As the ReAnimen pin and pummel the hero, William pleads with Rick, stirring memories of their past together. Sinclair slices William's arm to distract him, but the wound only jolts Rick's recognition. Rick tears out part of his own modifications, frees himself, and dismantles the other ReAnimen. Sinclair flees, takes several blows from William, then slams straight into Mark, who fractures his jaw. Cecil and the GDA arrest him and take his victims in hopes of reversing the damage.
In custody, Sinclair builds three more ReAnimen that Cecil describes as dead soldiers serving one final time. Pitted against Omni-Man, they hold their ground briefly before he decapitates one, crushes another's skull, and rips the third open, sickening the watching agents and infuriating Sinclair, who smashes a keyboard in frustration. After Nolan's exile from Earth, Cecil offers Sinclair redemption within the Global Defense Agency, where he begins crafting a newly designed generation of ReAnimen. The event unfolds during the first season's sixth episode.

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D.A. Sinclair is a former Upstate University student and professor who becomes convinced humanity can be perfected through surgery. He abducts people and rebuilds them into ReAnimen, mutilated soldiers with crushing strength who are bent to his will.
Doug Cheston, Sinclair's first victim, panics at the sight of the unfinished ReAnimen and escapes as a raging monster who tears across the college. He nearly overpowers Invincible, but upon glimpsing his own ruined face in a mirror he takes his own life in despair.
Rick, William's boyfriend turned into a ReAniman, is freed when William pleads with him and stirs memories of their past together. Rick then tears out part of his own modifications, frees himself, and dismantles the other ReAnimen.
After Invincible fractures his jaw and the Global Defense Agency arrests him, Sinclair's victims are taken in hopes of reversing the damage. Following Nolan's exile from Earth, Cecil later offers Sinclair redemption within the GDA, where he begins crafting a new generation of ReAnimen.
The Evolutionary Madness event unfolds in the sixth episode of Invincible's first season, You Look Kinda Dead (1x06).
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