Jack the Ripper is a minor antagonist in Phantom Blood, drawn from the infamous historical killer. A murderer in Victorian London, he is turned into a Zombie by Dio Brando and unleashed against the Joestar Group as one of Dio's first undead servants.
Jack is a grown man of average height and muscular frame, wearing an ordinary haircut and a short, full beard. He first appears in a complete suit, but once turned into a Zombie he bares his chest, the better to conceal an arsenal of blades within his own body.
In life Jack wears a veneer of gentlemanly manners, enough to coax a woman into an evening stroll before he knifes her without a shred of hesitation. Undeath only magnifies his cruelty and madness, leaving a creature driven by a single urge, to slash and to inflict pain.
After claiming his last human victim, Jack drew the notice of a then-crippled Dio Brando, who sensed the evil in him and chose him as the first of his Zombie minions; Jack resisted at first but gave in after failing to kill Dio, while the anime instead has Dio hypnotize him. As undead, he feels no pain and exploits this by burying scalpels beneath his skin, expelling and hurling them with deadly accuracy through sheer muscle contraction, and he also carries a monstrous knife rebuilt from an old torture device. His speed is fearsome enough to murder a man, behead two horses, and hide inside one within seconds.
Jack ambushes Jonathan Joestar, Robert Speedwagon and Will Zeppeli inside a tunnel on the road to Windknight's Lot, killing their coachman and mounts before flinging the coach across the entrance to seal them in. Zeppeli fights him to demonstrate the courage and power of the Ripple, wounding the Zombie, who slinks off into a hidden maze to strike from the dark. Zeppeli then sets Jonathan a final test, handing him a wine glass to fix Jack's position behind a wall; Jonathan drives a Sendo Hamon Overdrive through the brick and melts the killer away.

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Yes, Jack the Ripper appears in JoJo's Bizarre Adventure as a minor antagonist in Phantom Blood. He is drawn from the infamous historical killer and turned into one of Dio Brando's Zombie servants.
No, Dio Brando and Jack the Ripper are separate characters. After Jack claimed his last human victim, Dio sensed the evil in him and turned him into one of his Zombie minions.
Not exactly. Dio Brando turned Jack the Ripper into a Zombie, one of his undead servants, rather than a full vampire.
Jack the Ripper appears in the Phantom Blood arc of JoJo's Bizarre Adventure. He ambushes Jonathan Joestar, Robert Speedwagon, and Will Zeppeli inside a tunnel on the road to Windknight's Lot.
Jack the Ripper is wounded by Zeppeli's Ripple before retreating into a hidden maze to strike from the dark. Jonathan Joestar then pinpoints his position behind a wall using a wine glass and destroys him with a Sendo Hamon Overdrive.
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