Trained in the Ripple by Tonpetty, Straizo stands with Jonathan Joestar against Dio in Phantom Blood. Fifty years later, dreading old age, he dons a Stone Mask to become a vampire, turning on his old friend Speedwagon and hunting the young Joseph Joestar throughout Battle Tendency.
Straizo is a man of middling height and athletic build, his dark hair worn long and straight; the artbook JoJo 6251 outright calls him handsome. For the confrontation with Dio he pulls on a heavy tunic finished with wristbands, a large cloak, and knee pads. Aging changes his look little, but once he reclaims his youth he switches to a double-breasted jacket and a scarf woven from the wings of thirty thousand Satiporoja beetles gathered in Southeast Asia.
At first Straizo seems a principled Ripple warrior bent on stopping Dio's bid for world domination, forever declaring that he will show no mercy. In the fifty years before Battle Tendency he grows close to Speedwagon, who trusts him to destroy Santana. Yet his Ripple training only sharpened his sense of his own mortal limits, and having envied the vitality Dio gained as a vampire, he ultimately reaches for a Stone Mask when the Ripple can no longer hold back his aging.
He murders friends and followers in that pursuit and welcomes death, content to enter Hell young rather than as a withered corpse. Colder and more efficient than Dio, he refuses to toy with foes and moves to erase any threat at once, going after both Erina and Joseph for knowing of the mask; he even readies his beetle scarf specifically to cancel Joseph's Ripple and takes a hostage, wrenching out her tooth, to prove his resolve. Still, a shred of decency survives, and he warns Joseph of Santana's awakening, having also been a caring enough guardian that Lisa Lisa was left conflicted once she later learned Joseph had ended his life.
In Phantom Blood, Straizo is one of Tonpetty's disciples alongside Dire and Will Zeppeli. Answering Will's plea to destroy the Stone Mask, the group arrives too late to save him, so Straizo instead aids Jonathan against Dio, cutting down the quartet of Page, Jones, Plant, and Bornnam so that Poco and his sister stay safe, and there he witnesses a vampire's power up close.
After Jonathan's death, Erina entrusts him with the rescued infant Elizabeth, whom he raises as his own daughter, the future Ripple user Lisa Lisa; his Ripple mastery slows his own aging as he succeeds Tonpetty at the head of the order. Summoned to Mexico by Speedwagon, he first passes the immaculate Super Aja, a Red Stone of Aja, to Lisa Lisa for safekeeping. There Speedwagon leads him beneath a newly found pyramid to the Pillar Man he wants destroyed, but Straizo, having read the translation notes and probed Joseph's skill, turns on them, slaughtering the disciples and Speedwagon's men. He confesses his long envy of Dio's youth, activates a Stone Mask with his victims' blood, and dumps Speedwagon and the bodies in a river before setting out to erase every witness, the Joestars included.
Now a vampire able to wield both regeneration and the Space Ripper Stingy Eyes, he stalks Joseph in New York. Joseph blasts him through a bar window with a Tommy gun, but the beetle scarf blunts the Ripple; Joseph answers by lashing grenades to that scarf, and the blast scatters Straizo into fragments that slowly knit back together. Regenerated, he seizes a reporter and confronts Joseph on the Brooklyn Bridge, tearing out her tooth to force a fight. Joseph deflects the eye beams with Ripple-charged shot glasses and punches him off the span. Caught at the last instant and pressed about Speedwagon, Straizo warns of the coming Pillar Man Santana before unleashing his stored Ripple to destroy himself, unrepentant and glad to die in his prime.

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Straizo begins as a principled Ripple warrior who fights alongside Jonathan Joestar against Dio in Phantom Blood, but fifty years later he dons a Stone Mask out of fear of aging, becoming a cold, murderous vampire who turns on his old allies.
In Battle Tendency, Straizo becomes a vampire, slaughters Speedwagon's men, and hunts Joseph Joestar in New York. After a drawn out fight on the Brooklyn Bridge, Joseph corners him, and Straizo uses his remaining Ripple to destroy himself, warning Joseph of Santana's awakening first.
Straizo's decades of Ripple training only sharpened his awareness of his own mortality, and having long envied the vitality Dio gained as a vampire, he ultimately dons a Stone Mask to escape old age, murdering friends and followers along the way.
After becoming a vampire, Straizo sets out to erase every witness to his transformation, including Joseph Joestar, since Joseph knows of the Stone Mask and poses a threat to his secret.
Yes, after Jonathan Joestar's death, Erina entrusts the rescued infant Elizabeth to Straizo, who raises her as his own daughter. She grows up to become the Ripple master Lisa Lisa.
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