Luminescence made a newborn glow, and that glow is where the whole superhuman age begins. It is the first Quirk anyone thought to write down, which is precisely why All For One took it, murdering its infant owner and carrying the light with him for the rest of his long life.
Luminescence is a self-range Emitter ability, and its name is conjectural rather than official, since the series never actually settles on one. The Meta Ability originally belonged to the Luminescent Baby and passes to All For One after he steals it. Both the manga's first chapter and the anime's first episode establish it.
Its significance is historical. This is the earliest Quirk entered into recorded history, and its registration is what pushed the world to acknowledge that superpowers were real. That distinction comes with an asterisk, though. It was not the first to appear: the mother of the Shigaraki brothers had already manifested Spearlike Bones more than two years earlier, and reports placed roughly fifty other cases in India alone, with more scattered worldwide, before anyone logged Luminescence.
The ability floods the owner's body with brilliant light, producing a living bioluminescence.
It was already running when the baby was newly born, and it presumably would have grown more potent as the child matured. Whether the original bearer could shut it off, or whether the glow simply never stopped, was never established. All For One, by contrast, demonstrably switches it on and off as he pleases.
The two adaptations distinguish them visually, though the manga draws no such line. On screen the infant radiates clean white light, while All For One's entire frame burns a muddier orange-yellow, matching the color the moon wore on the night he claimed the Quirk.
The Luminescent Baby is the original holder and the reason the world learned the word Quirk at all. All For One took the ability and then killed the child, afterward parading the light in front of his brother Yoichi Shigaraki as a boast.
He returns to it near the end. During the Final War, after the rewinding drug regresses him into a young boy, All For One calls up the glow once more in his closing duel with Toshinori Yagi.

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No, All For One is not the Luminescent Baby. He stole the Luminescence Quirk from the infant and killed the child afterward, then carried the ability with him for the rest of his life.
All For One glows because he possesses the stolen Luminescence Quirk, an Emitter ability that floods the user's body with light, and he can switch the glow on and off at will.
Luminescence is a self-range Emitter Quirk that produces a living bioluminescence, making the user's body radiate light.
My Hero Academia does not give an explicit motive, but Luminescence holds special significance as the first Quirk ever registered in recorded history. After stealing it and killing its original owner, All For One paraded the glow in front of his younger brother Yoichi Shigaraki as a boast.
Luminescence was the first Quirk officially registered in recorded history, but it was not truly the first to appear. The mother of the Shigaraki brothers had already manifested Spearlike Bones more than two years earlier, and roughly fifty other cases were reported in India alone before Luminescence was logged.
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