The opening saga of the series carries a powerless boy from schoolyard bullying to the inheritance of the world's greatest Quirk, introduces the enemy who wants the Symbol of Peace dead, and ends with the retirement of the man everyone believed would never fall.
This is the first saga of My Hero Academia, gathering Volumes 1 through 11, Chapters 1 to 97, and Episodes 1 to 50. The manga ran it from July 2014 to July 2016 and the anime adapted it between April 2016 and June 2018. The Rise of Villains Saga follows.
Three threads define it: One For All passing from Toshinori Yagi into Izuku Midoriya's hands, a villain organization stepping onto the board under Tomura Shigaraki, and the retirement that closes out All Might's era.
Izuku is born without a Quirk and wants to be a hero anyway. Katsuki Bakugo makes his childhood miserable, and then the top hero in Japan chooses him as an heir. Training gets him through the U.A. entrance exam and into a class of students he quickly comes to care about, though One For All wrecks his body every time he draws on it.
Class 1-A is ambushed by the League of Villains, whose leader Tomura Shigaraki wants All Might dead so that the country loses its Symbol of Peace and tips into chaos. The attempt fails and he withdraws. The U.A. Sports Festival follows, a showcase in front of the whole country, where Izuku learns what Shoto Todoroki has survived and helps him accept himself, while Katsuki takes the championship by beating Shoto in the final.
Internships send the students out to work beside professionals. Izuku trains under Gran Torino, All Might's own teacher, and gets caught in a League attack on Hosu City involving their Nomu. He also reaches Tenya Ida before the Hero Killer Stain can finish what Tenya's revenge started, and with Shoto's help the three take Stain down, an outcome that ironically converts more villains to the man's ideology and to the League.
As the term closes, All Might tells Izuku the truth about where One For All came from and about All For One, the villain he believes is behind everything. Final exams pit the class against their own teachers, and Izuku and Katsuki barely survive All Might by working together. Summer camp with Class 1-B is meant to sharpen their Quirks; instead the League attacks and carries Katsuki off, intending to turn him.
Professionals assemble a raid on the League's hideout to recover Katsuki, while Izuku and a handful of friends go in unsanctioned to do it themselves. All For One appears in person, and the brutal fight that follows ends with All Might victorious and spent, the last embers of One For All burned out of him.
He retires from heroics. The country has its peace and no longer has its symbol, and the saga closes with the next generation left to carry what he set down.

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The U.A. Beginnings Saga is the first saga of My Hero Academia, covering volumes 1 through 11 and chapters 1 to 97. It follows Izuku Midoriya from a powerless boy into the inheritor of One For All, ending with All Might's retirement.
Izuku Midoriya inherits One For All after All Might, the top hero in Japan, chooses him as a successor despite Izuku being born without a Quirk. The training that follows helps him pass the U.A. entrance exam, though using the power at first wrecks his body every time.
The U.A. Sports Festival is a nationally televised showcase where Izuku Midoriya learns what Shoto Todoroki has survived and helps him accept his own power. Katsuki Bakugo wins the championship by defeating Shoto in the final match.
Stain is the Hero Killer who attacks Tenya Ida during the U.A. Beginnings Saga's internship arc. Izuku Midoriya, Tenya Ida, and Shoto Todoroki work together to defeat him, though the fight ironically inspires more villains to join the League of Villains.
All Might retires after a brutal battle against All For One during a raid to rescue the kidnapped Katsuki Bakugo. The fight burns out the last embers of One For All left in his body, leaving the country without its Symbol of Peace as the saga closes.
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