
Chapter 578 of the Naruto manga splits between two fronts. Sasuke reaches Kabuto's lair set on reaching his brother, while on the battlefield Tsunade unveils seal-free regeneration and Madara answers the five Kage with a small army of wood clones.
Arriving at Kabuto's hideout, Sasuke names him at once. Kabuto tries to steer him into turning on Itachi, but Sasuke makes clear he came to speak with his brother and that Kabuto, having assumed Orochimaru's role, is the one he opposes. Far away, Tsunade demonstrates a technique that heals her instantly without any hand seals and hurls the blade impaling her straight back at Madara.
Madara draws the sword into his Susanoo, and when Ōnoki strikes from behind with Dust Release, he simply absorbs that too, boasting he could have done so sooner but chose to unnerve them with Hashirama's face instead. Tsunade challenges his bravado, pointing out that the Kage pushed him into relying on a wood clone. Rather than deny it, Madara concedes that five against one is a fair count and conjures twenty-five wood clones, five to meet each Kage.

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Back at the hideout, Sasuke moves to kill Kabuto, but Itachi halts him, insisting they first uncover how to undo the Impure World Reincarnation. Sasuke agrees to help on the condition that Itachi answer his questions once the task is finished, and Itachi consents as the brothers and Kabuto brace for combat. The chapter falls within the Fourth Shinobi World War: Climax arc and is collected in volume 61; Viz titles it 'The Weak Point of Despair'.
In "The Weakness of Despair!!" (chapter 578), Sasuke Uchiha arrives at Kabuto's hideout intending to confront his brother Itachi, while Tsunade unveils a seal-free healing technique against Madara Uchiha on the battlefield.
Tsunade demonstrates a technique that heals her wounds instantly without hand seals, then hurls the blade that had impaled her straight back at Madara Uchiha.
Madara absorbs Onoki's Dust Release attack into his Susanoo, and after Tsunade points out his reliance on a wood clone, he concedes the point and conjures twenty-five wood clones, five to meet each Kage.
Itachi stops Sasuke from killing Kabuto because they first need Kabuto to find a way to undo the Impure World Reincarnation, and Sasuke agrees to help if Itachi answers his questions once the task is finished.
"The Weakness of Despair!!" is chapter 578 of the Naruto manga, part of the Fourth Shinobi World War: Climax arc collected in volume 61, and Viz titles it "The Weak Point of Despair."
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