Synthetic copies of naturally occurring Devil Fruits, these are built by tampering with the Lineage Factor so a single power can belong to several people at once. Developed on separate tracks by Dr. Vegapunk and Caesar Clown, they produced Momonosuke's dragon form, the factory-made SMILE fruits, and the Seraphim's borrowed abilities.
Every one of these lab-grown fruits traces back to Vegapunk's study of the way a Devil Fruit reshapes its eater's Lineage Factor, a discovery he then turned toward the blood itself. Two scientists once tied to the research body MADS pulled the feat off, yet by very different routes. Serving the World Government, Vegapunk started from the Lineage Factor of a person who already ate a fruit and eventually copied both Zoan powers and a few Paramecia ones, whereas Caesar Clown relied on the Lineage Factor of everyday beasts and could only churn out Zoan-style imitations.
By Vegapunk's own admission, even the cleverest mind alive struggled to forge a true Devil Fruit, and Logia abilities defied recreation entirely. Both men's products steal the swimmer's talent just as a real fruit would. Manufactured Zoans also look nothing like the genuine article, coming out as sleek, apple-like objects marked with a ring rather than the familiar swirl, and their powers vanish outright at the eater's death instead of reappearing in a new fruit.
Zoan stands as the sole class that can be fabricated in full, and Vegapunk held that any Zoan, a Mythical one included, was reproducible with sufficient funds and patience, though nobody knows if such powers can awaken. Caesar builds his SMILE fruits by soaking natural fruits in the chemical SAD, but rather than tidy shifts they sprout animal parts from the eater's frame, and their strength trails well behind real Zoans. Roughly one in ten SMILEs actually confers a power; the rest are duds that strip the consumer of ability, take away swimming, and lock their expressions to joy alone, the merciless quirk from which the fruits earned their label.
No Paramecia fruit can be rebuilt as an object, yet the powers themselves are still copyable. Distilling a purpose-made fluid called Green Blood from a genuine user's bloodline components allows those powers to be transferred into someone else. That process underpins the Seraphim weapons, whose copied Paramecia gifts course through the Green Blood in their limbs.
Kouzuki Momonosuke consumed the artificial Zoan Vegapunk branded a flop, one patterned on Kaidou's Uo Uo no Mi through the Emperor's Lineage Factor. Labeled a dud purely because its dragon shape emerged pink where the original was blue, the fruit lets the boy become a yellow-maned dragon and summon Flame Clouds, with his early trouble over size and command later traced to his tender age rather than the fruit.
The Beasts Pirates hoarded Caesar's SMILEs and fed them to about 5000 recruits, producing some 500 working Gifters against roughly 4500 dud-swallowing Pleasures. Vegapunk's Green Blood, in turn, fitted the Seraphim with stand-ins for Paramecia powers, so that S-Shark carries the Sui Sui no Mi, S-Bear the Nikyu Nikyu no Mi, S-Snake the Mero Mero no Mi, and S-Hawk the Supa Supa no Mi.

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Several characters carry artificial Devil Fruits, including Kouzuki Momonosuke, whose dragon form comes from an artificial copy of Kaidou's Uo Uo no Mi. The Beasts Pirates' SMILE eating Gifters and Vegapunk's Seraphim weapons also carry artificial or copied Devil Fruit powers.
An Artificial Devil Fruit is a synthetic copy of a naturally occurring Devil Fruit, built by tampering with a person's Lineage Factor so that a single power can be given to more than one user. They were developed on separate tracks by Dr. Vegapunk and Caesar Clown.
Artificial Devil Fruits were created by two scientists formerly tied to the research body MADS: Dr. Vegapunk, working for the World Government, and Caesar Clown. Both men used different methods to reproduce natural Devil Fruit powers.
Vegapunk started from the Lineage Factor of a person who already ate a real fruit and managed to copy both Zoan powers and some Paramecia powers. Caesar Clown, by contrast, relied on the Lineage Factor of ordinary animals and could only produce Zoan style imitations.
SMILE fruits are Caesar Clown's artificial Devil Fruits, made by soaking natural fruits in a chemical called SAD so the eater sprouts animal parts. Only about one in ten actually grants a power, making the eater a Gifter, while the rest are duds called Pleasures that remove the ability to swim and lock the eater's expression to joy.
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