The Donquixote Family is one of the twenty royal houses that founded the World Government eight centuries ago and one of the nineteen that resettled in Mary Geoise as World Nobles. Once rulers of Dressrosa, the bloodline fell into ruin after Donquixote Homing renounced his Celestial Dragon status, setting his son Doflamingo on a path of vengeance.
Before the World Government existed, this dynasty governed the kingdom of Dressrosa. When the unnamed king of the line accepted an invitation to relocate, the family abandoned their realm and joined the founding twenty, taking up residence in Mary Geoise as Celestial Dragons while the Riku Family inherited the throne they left behind. Their history stretches back past the Void Century, and even in those distant days the house carried a cruel reputation, having once enslaved the Tontatta dwarves. The dynasty splits into branches, the most prominent being the small household of Homing and his two sons, alongside a separate line that produced Shivercalero and his son Mjosgard.
The family's defining turn came when Donquixote Homing surrendered the World Noble titles of himself, his wife, and his two boys, choosing to live as ordinary people in a North Blue country with no ties to the government. That choice ended in disaster. Once the locals learned former Celestial Dragons lived among them, the family's manor was torched and they were driven into a junkyard, where the mother died of illness brought on by poverty. Caught and tortured by vengeful townsfolk, the young Doflamingo blamed his father for their ruin. Two years later his awakened Conqueror's Haki, plus a Devil Fruit and pistol gifted by Trebol, let him murder Homing and seek reentry to Mary Geoise, only to be turned away as a traitor's child. Decades on, Doflamingo retook the Dressrosa throne and held it for ten years before Luffy and Law tore it from him.
Donquixote Homing served as the patriarch whose idealism doomed his household. His elder son, Donquixote Doflamingo, became the family's most infamous figure, a pirate and Warlord who usurped Dressrosa and ran a vast underworld trade until his defeat sent him to Impel Down. The younger son, Rosinante, broke from his brother to become a Marine spy and was killed by Doflamingo for his betrayal. From the other branch, Donquixote Mjosgard began as a slave-owning World Noble but reformed after Queen Otohime saved his life, later defending Fish-Man Island's people. He was eventually executed and crucified by Figarland Garling for shielding the fish-man race.

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The Donquixote Family includes patriarch Donquixote Homing and his two sons, Donquixote Doflamingo and Rosinante, from one branch, and Donquixote Mjosgard from a separate branch descended from Shivercalero.
The Donquixote Family still exists in a diminished form. Homing and his wife are dead, Rosinante and Mjosgard were both killed, and Doflamingo remains alive after his defeat sent him to Impel Down.
Donquixote Mjosgard and Donquixote Doflamingo both belong to the Donquixote Family but come from different branches. Doflamingo descends from Homing's line, while Mjosgard comes from a separate branch through Shivercalero.
Donquixote Homing surrendered his family's World Noble titles out of idealism, choosing to live as an ordinary person in a North Blue country instead of remaining a Celestial Dragon in Mary Geoise.
After Homing renounced his status, locals learned of his family's Celestial Dragon past and burned their manor, driving them into a junkyard where his wife died of illness; the tragedy eventually pushed young Doflamingo to kill his own father.
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